- 1995
- Sports Image Foundation Award for conducting tennis clinics in low-income areas
- 1997
- WTA Newcomer of the Year
- September's Olympic Committee Female Athlete
- 1998
- Tennis Magazine's Most Improved Player
- 2000
- WTA Player of the Year
- WTA Doubles Team of the Year Award (with Serena Williams)
- Sports Illustrated for Women's Sportswoman of the Year
- Teen Choice Awards – Extraordinary Achievement Award
- Forbes The Celebrity 100 (No.62)
- Women's Sports Foundation Sportswoman of the Year for team sports (with Serena Williams)
- 2001
- Best Female Tennis Player ESPY Award
- EMMA Best Sport Personality Award
- Forbes The Celebrity 100 (No.57)
- 2002
- Best Female Athlete ESPY Award
- Best Female Tennis Player ESPY Award
- Forbes The Celebrity 100 (No.60)
- 2003
- 34th NAACP Image Awards' President's Award
- Forbes The Celebrity 100 (No.65)
- 2004
- Harris Poll Top 10 Favorite Female Sports Star (No.1)
- Forbes The Celebrity 100 (No.77)
- 2005
- Glamour Magazine's Women of the Year Award
- Forbes The Celebrity 100 (No.81)
- Harris Poll Top 10 Favorite Female Sports Star (No.3)
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- 2006
- Best Female Tennis Player ESPY Award
- BET's Best Female Athlete of the Year
- Harris Poll Top 10 Favorite Female Sports Star (No.1)
- Forbes The Celebrity 100 (No.90)
- 2007
- Gitanjali Diamond Award
- Harris Poll Top 10 Favorite Female Sports Star (No.3)
- 2008
- Whirlpool 6th Sense Player of the Year Award
- Harris Poll Top 10 Favorite Female Sports Star (No.3)
- 2009
- Anti-Defamation League Americanism Award
- Whirlpool 6th Sense Player of the Year Award
- ITF Women's Doubles World Champion (with Serena Williams)
- WTA Doubles Team of the Year Award (with Serena Williams)
- WTA Fan Favorite Doubles Team of the Year Award (with Serena Williams)
- Doha 21st Century Leaders Awards – Outstanding Leadership
- Forbes The Celebrity 100 (No.77)
- Harris Poll Top 10 Favorite Female Sports Star (No.2)
- 2010
- Caesars Tennis Classic Achievement Award
- Forbes The Celebrity 100 (No.83)
- YWCA GLA Phenomenal Woman of the Year Award
- WTA Fan Favorite Doubles Team of the Year Award (with Serena Williams)
- Forbes 30 Utterly Inspiring Role Models
- Forbes 100 Most Powerful Women in the World (No.60)
- Harris Poll Top 10 Favorite Female Sports Star (No.2)
- 2011
- Forbes The Celebrity 100 (No.86)
- TIME Magazine 30 Legends of Women's Tennis
- Forbes Most Powerful Black Women In The U.S. (No.10)
- Harris Poll Top 10 Favorite Female Sports Star (No.2)
- 2012
- World TeamTennis Finals Most Valuable Player
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