Mechanism of Action
Vagus, the tenth cranial nerve, arises from the medulla and carries both afferent and efferent fibers. The afferent vagal fibers connect to the nucleus of the solitary tract which in turn projects connections to other locations in the central nervous system. Little is understood about exactly how vagal nerve stimulation modulates mood and seizure control but proposed mechanisms include alteration of norepinephrine release by projections of solitary tract to the locus coeruleus, elevated levels of inhibitory GABA related to vagal stimulation and inhibition of aberrant cortical activity by reticular system activation.
Randomized control trials indicated that thirty-percent of patients would have a greater than fifty-percent reduction of seizures. On average, about fifty-percent of patients experience a forty percent or greater reduction in seizure frequency and severity. About 75% of patients choose to have the battery replaced (continue with the therapy).
Read more about this topic: Vagus Nerve Stimulation
Famous quotes containing the words mechanism of, mechanism and/or action:
“The two elements the traveler first captures in the big city are extrahuman architecture and furious rhythm. Geometry and anguish. At first glance, the rhythm may be confused with gaiety, but when you look more closely at the mechanism of social life and the painful slavery of both men and machines, you see that it is nothing but a kind of typical, empty anguish that makes even crime and gangs forgivable means of escape.”
—Federico García Lorca (1898–1936)
“I’ve never known a Philadelphian who wasn’t a downright “character;” possibly a defense mechanism resulting from the dullness of their native habitat.”
—Anita Loos (1888–1981)
“The most fruitful and natural exercise of our mind, in my opinion, is discussion. I find it sweeter than any other action of our life.”
—Michel de Montaigne (1533–1592)