The first USS Housatonic was a screw sloop-of-war of the United States Navy, named for the Housatonic River of New England which rises in Berkshire County, Massachusetts, and flows southward into Connecticut before emptying into Long Island Sound a little east of Bridgeport, Connecticut. Housatonic was the first ship in history to be sunk by a submarine.
Housatonic was launched on 20 November 1861, by the Boston Navy Yard at Charlestown, Massachusetts, sponsored by Miss Jane Coffin Colby and Miss Susan Paters Hudson; and commissioned there on 29 August 1862, with Commander William Rogers Taylor in command. Housatonic was one of four sister ships which included USS Adirondack, USS Ossipee, and USS Juniata.