The fourth USS Gridley (DDG-101) is the fifty-first Arleigh Burke-class destroyer in the United States Navy. Gridley is named after Captain Charles Gridley, Commander of Admiral George Dewey's flagship Olympia, (Flag Captain) and recipient of Admiral Dewey's famous command, "You may fire when you are ready, Gridley" in the Battle of Manila Bay during the Spanish-American War.
In May 2004, the Secretary of the Navy announced the names of five new Arleigh Burke class destroyers, including Gridley. Her keel was laid on 30 July 2004 at the Bath Iron Works in Bath, Maine. She was christened on 11 February 2006. The Gridley was commissioned at the Port of Miami on Saturday, 10 February 2007.
She has joined the Pacific Fleet and is homeported at Naval Base San Diego.
Gridley departed Naval Base San Diego on 19 May 2008 for her maiden deployment and returned on 25 November 2008.