In the fictional Star Trek universe, there have been a number of starships named Enterprise (where the designation refers to United Federation of Planets Star Ship rather than United States Ship):
- USS Enterprise (XCV 330) Declaration class (circa 2130s) from art in Star Trek: The Motion Picture, and the series Star Trek: Enterprise.
- Enterprise (NX-01) NX class (2151–2161) from the series Star Trek: Enterprise.
- USS Enterprise (NCC-1701) Constitution class (2245–2285) from the original Star Trek series, the animated Star Trek and the first three films and 2009's Star Trek.
- USS Enterprise (NCC-1701-A) Constitution (also listed as Enterprise) class (2286–2293) from the films The Voyage Home, The Final Frontier and The Undiscovered Country.
- USS Enterprise (NCC-1701-B) Excelsior class (2293–2320s) from the film Generations.
- USS Enterprise (NCC-1701-C) Ambassador class (2332–2344) from the Star Trek: The Next Generation episode "Yesterday's Enterprise".
- USS Enterprise (NCC-1701-D) Galaxy class (2363–2371) from the series Star Trek: The Next Generation and film Generations.
- USS Enterprise (NCC-1701-E) Sovereign class (2372—) from the films First Contact, Insurrection, and Nemesis
- USS Enterprise (NCC-1701-F) Odyssey class (2409-) from Star Trek Online "prime" time line
- USS Enterprise (NCC-1701-J) (26th century) from the Star Trek: Enterprise episode "Azati Prime"
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