Two ships in the United States Navy have been named USS Effingham:
- The USS Effingham
- Frigate under construction for the Continental Navy, but burned before she ever saw service. Named for Thomas Howard, 3rd Earl of Effingham - an English nobleman who resigned his commission rather than fight an unjust war against the American colonists.
- The USS Effingham (APA-165)
- Transport used during World War II, and named for Effingham County, Georgia and Effingham County, Illinois.
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