Two United States Navy destroyers have borne the name USS Cole. The first Cole was named for Edward B. Cole. The second ship was named for Darrell S. Cole.
- USS Cole (DD-155) was a Wickes-class destroyer, which was launched in 1919 and stricken in 1945.
- USS Cole (DDG-67) is an Arleigh Burke-class "Aegis" guided missile destroyer, launched in 1995. On 12 October 2000 she was attacked and damaged by suicide bombers using a small inflatable boat. See USS Cole bombing.