Major Intersections
- Mexican Federal Highway 45 at the U.S.-Mexico border between El Paso, Texas and Ciudad Juárez, Chih.
- U.S. Highway 62 in El Paso
- Interstate 10 and U.S. Route 180 in El Paso
- Interstate 25 and U.S. Highway 70 in Las Cruces, New Mexico
- Interstate 40 in Albuqurerque, New Mexico
- U.S. Highway 64 in Raton, New Mexico
- U.S. Highway 350 in Trinidad, Colorado
- U.S. Highway 160 near Walensburg, Colorado
- U.S. Highway 50 in Pueblo, Colorado
- U.S. Highway 24 in Colorado Springs, Colorado
- U.S. Highway 285 in Englewood, Colorado
- Interstate 25 south of downtown Denver, Colorado (intersects with I-25/US-87)
- U.S. Highway 40 and U.S. Highway 287 in Denver, Colorado (paired together)
- Interstate 70 in Denver, Colorado
- U.S. Highway 36 and Interstate 270 north of Denver, Colorado (paired together)
- U.S. Highway 6 and Interstate 76 north of Denver, Colorado (they are paired with U.S. 85)
- U.S. Highway 34 in Greeley, Colorado
- Interstate 80 in Cheyenne, Wyoming
- U.S. Highway 30 in Cheyenne, Wyoming
- U.S. Highway 87 north of Cheyenne, Wyoming
- U.S. Highway 26 in Lingle, Wyoming
- U.S. Highway 20 in Lusk, Wyoming
- U.S. Highway 18 west of Edgemont, South Dakota
- U.S. Highway 16 in Newcastle, Wyoming
- U.S. Highway 14 in Deadwood, South Dakota
- U.S. Highway 385 in Deadwood, South Dakota
- Interstate 90 and U.S. Highway 14 in Spearfish exit 10
- U.S. Highway 212 in Belle Fourche, South Dakota
- U.S. Highway 12 in Bowman, North Dakota
- Interstate 94 exit 42 at Belfield, North Dakota
- U.S. Highway 2 north of Williston, North Dakota
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