U.S. Route 491

U.S. Route 491 (US 491) is a north–south U.S. Highway serving the Four Corners region of the United States. One of the newest designations in the U.S. Highway System, it was created in 2003 as a renumbering of U.S. Route 666 (US 666). With the 666 designation, this road was nicknamed the "Devil's Highway" because of the belief by many Christians that 666 is the Number of the Beast. This Satanic connotation, combined with a high fatality rate along the New Mexico portion, convinced some people the highway was cursed. The problem was compounded by persistent sign theft. These factors led to two efforts to renumber the highway, first by officials in Arizona, later in New Mexico. There have been safety improvement projects in recent years, and fatality rates have subsequently decreased.

The highway runs through Colorado, New Mexico and Utah, as well as the tribal nations of the Navajo Nation and Ute Mountain Ute Tribe. The highway passes by two mountains considered sacred by native Americans, Ute Mountain and an extinct volcanic core named Shiprock. Other features along the route include Mesa Verde National Park and Dove Creek, Colorado, the self-proclaimed pinto-bean capital of the world.