U.S. Route 45 is a north–south United States highway. US 45 is a border-to-border route, from Lake Superior to the Gulf of Mexico. A sign at the highway's northern terminus notes the total distance as 1,300 miles (2,100 km).
US 45 is notable for incorporating, in its maiden alignment, the first paved road in the South, a 49-mile segment in Lee County, Mississippi. Let to contract in July 1914, the concrete highway opened on November 15, 1915.
As of 2006, the highway's northern terminus is in Ontonagon, Michigan, at the corner of Ontonagon and River Streets, a few blocks from Lake Superior. M-64 formerly terminated there as well until its rerouting in October 2006 to use the newly built Ontonagon River Bridge. Its southern terminus is in Mobile, Alabama, at an intersection with U.S. Route 98.
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