U.S. Route 421 - Major Intersections

Major Intersections

  • Fort Fisher, North Carolina (southern end)
  • U.S. Route 117 in Wilmington, North Carolina
  • U.S. Route 17 / U.S. Route 74 / U.S. Route 76 in Wilmington
  • Interstate 140 north of Wilmington
  • U.S. Route 701 in Clinton, North Carolina
  • U.S. Route 13 southeast of Dunn, North Carolina
  • Interstate 95 at Dunn
  • U.S. Route 301 at Dunn
  • U.S. Route 401 at Lillington, North Carolina
  • U.S. Route 1 / U.S. Route 15-501 in Sanford, North Carolina
  • U.S. Route 64 at Siler City, North Carolina
  • Interstate 85 at Greensboro, North Carolina
  • Interstate 40 / Interstate 85 Business / U.S. Route 29 / U.S. Route 70 / U.S. Route 220 at Greensboro
  • Interstate 73 at Greensboro
  • Interstate 40 Business / U.S. Route 158 near Winston-Salem, North Carolina
  • U.S. Route 52 / U.S. Route 311 at Winston-Salem
  • U.S. Route 601 at Yadkinville, North Carolina
  • U.S. Route 21 west of Yadkinville
  • Interstate 77 west of Yadkinville
  • U.S. Route 221 / U.S. Route 321 at Boone, North Carolina
  • State Route 67 at Trade, Tennessee
  • State Route 133 at Shady Valley, Tennessee
  • State Route 394 at Bristol, Tennessee

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