Route Description
US 378 has a length of 23.41 miles (37.67 km) in Georgia and spans 210.89 miles (339.39 km) in South Carolina. The U.S. Highway is a part of the National Highway System from US 178 in Saluda east to South Carolina Highway 12 (SC 12) in West Columbia and from US 1 in Columbia east to US 501 and US 701 in Conway.
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