U.S. Route 285

U.S. Route 285 is a north–south United States highway, running 845 miles (1,260 km) through the states of Texas, New Mexico and Colorado. The highway's southern terminus is in Sanderson, Texas at an intersection with U.S. Route 90. US 285 has always had an endpoint in Denver, Colorado, though what is now the northern terminus was once the route's southern end, and the former portion north of Denver now does not exist. The highway's northern terminus is in Denver, Colorado, at exit 201 on Interstate 25. Trucking makes up a large portion of the route's traffic, but along much of its route the road is also used for local travel from one town to the next.

The route is a secondary route of US 85, though its parent route has been largely replaced by Interstate 25. It crosses a sibling route, US 385 in Fort Stockton, Texas.

The northern section of the route, from Santa Fe, New Mexico to Denver, Colorado traverses mountainous and rocky terrain; with that in mind, anyone using the road should check weather conditions during the winter months.

As of January 2007 the road is under construction between Espanola and Santa Fe, New Mexico, as part of a long term project to upgrade that section of the highway to a limited access thoroughfare.