Major Intersections
- U.S. Route 59/U.S. Route 71 at Wickes, Arkansas
- U.S. Route 70 at Dierks, Arkansas
- U.S. Route 371 at Nashville, Arkansas
- Interstate 30 at Hope, Arkansas
- U.S. Route 67 at Hope, Arkansas
- U.S. Route 371 at Rosston, Arkansas
- U.S. Route 79 at Camden, Arkansas
- U.S. Route 167 at Hampton, Arkansas
- U.S. Route 63 at Warren, Arkansas
- U.S. Route 425 at Monticello, Arkansas
- U.S. Route 65 from McGehee to Lake Village, Arkansas
- U.S. Route 82 from Lake Village, Arkansas to Leland, Mississippi
- U.S. Route 61 from Leland to Clarksdale, Mississippi
- U.S. Route 49 at Clarksdale, Mississippi
- Interstate 55 at Batesville, Mississippi
- U.S. Route 45 at Okolona, Mississippi
- U.S. Route 78 (future Interstate 22) at Hamilton, Alabama
- U.S. Route 43 from Guin to Hamilton, Alabama
- Interstate 65 at Cullman, Alabama
- U.S. Route 31 at Cullman, Alabama
- U.S. Route 231 near Snead, Alabama
- U.S. Route 11 at Attalla, Alabama
- U.S. Route 431 from Attalla to Gadsden, Alabama
- Interstate 59 at Gadsden, Alabama
- GA S.R. 61 at Dallas, Georgia
- U.S. Route 27 at Cedartown, Georgia
- U.S. Route 78 from Lithia Springs to Druid Hills, Georgia
- Interstate 75/Interstate 85 at Atlanta, Georgia
- Interstate 285 at Decatur, Georgia
- U.S. Route 129/U.S. Route 441 at Madison, Georgia
- Interstate 20 at Barnett, Georgia
- U.S. Route 221 at Harlem, Georgia
- U.S. Route 25 at Augusta, Georgia
- Interstate 520 east of Augusta, Georgia
- U.S. Route 301 at Allendale, South Carolina
- U.S. Route 321 at Fairfax, South Carolina
- U.S. Route 601 at Hampton, South Carolina
- U.S. Route 17 from Ridgeland to Hardeeville, South Carolina
- Interstate 95 at Hardeeville, South Carolina
Read more about this topic: U.S. Route 278
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