Major Intersections
- US 1 in Rockingham, North Carolina
- I-73 near Candor, North Carolina
- US 64 in Asheboro, North Carolina
- I-85 / US 421 in Greensboro, North Carolina
- I-40 in Greensboro, North Carolina
- US 58 in Martinsville, Virginia
- I-81 near Roanoke, Virginia
- US 50 in New Creek, West Virginia
- US 33 in Franklin, West Virginia
- I-68 / US 40 in Cumberland, Maryland
- Pennsylvania Turnpike (I-70 and I-76) near Bedford, Pennsylvania
- overlaps with I-99 from Bedford to Bellefonte, Pennsylvania
- US 22 near Altoona, Pennsylvania
- US 322 in State College, Pennsylvania
- I-80 near Bellefonte, Pennsylvania
- I-180 / US 15 in Williamsport, Pennsylvania
- US 6 in Towanda, Pennsylvania
- NY 17 in South Waverly, Pennsylvania
Read more about this topic: U.S. Route 220
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