U.S. Route 22 (US 22) is a west–east route and is one of the original United States highways of 1926, running from Cincinnati, Ohio, at US 27, US 42, US 127, and US 52 to Newark, New Jersey, at U.S. Route 1/9 in the Newark Airport Interchange. US 22 also carries the names of the William Penn Highway throughout most of Pennsylvania. In southwest Ohio, it overlaps with Ohio State Route 3 and is familiarly known as the 3C Highway, "22 and 3", and Montgomery Road.
A section of US 22 between New Alexandria at U.S. Route 119 and Harrisburg at Interstate 81 has been designated a part of Corridor M of the Appalachian Development Highway System.
Read more about U.S. Route 22: History
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