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The faculty of this university discussed the feasibility of Christopher Columbus's project and the effects his claims brought. Once America was discovered, they discussed the rights of indigenous people as being recognized with full plenitude, which was revolutionary for that period, economic processes were analyzed for the first time and they developed the science of law as it became a classical scholarly focus. It was the period when some of the brightest minds attended the university and it was known as the School of Salamanca. The schools members renovated theology, laid the foundation for modern-day law, international law, modern economic science and actively participated in the Council of Trent. The school's mathematicians studied the calendar reform, commissioned by Pope Gregory XIII and proposed the solution that was later implemented. By 1580, 6,500 new students had arrived at Salamanca each year, amongst the graduates were state officials of the Spanish monarchy administration were nourished. It was also during this period when the first female university students were probably admitted, Beatriz Galindo and LucĂa de Medrano, the latter being the first woman ever to give classes at a university.
The university saw a decline in the seventeenth century.
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