Alumni
- Lokmanya Tilak – Maker of modern India, Indian nationalist leader, savant, philosopher, mathematician.
- B. R. Ambedkar – Architect of modern India & Author of the Constitution of India, social reformist and thinker.
- Lal Krishna Advani – Former Deputy Prime Minister of India
- John Abraham - Bollywood actor.
- Justice Mushtak Ali Kazi – Judge, High Court of Sindh & Balochistan, Pakistan.
- Kona Prabhakara Rao – Governor of Maharashtra, Lt. Governor of Pondicherry, Governor of Sikkim, Finance Minister of Andhra Pradesh, Speaker of AP State Assembly
- Ahmed Hussain A Kazi – Secretary to Government of Pakistan and Chairman Pakistan Industrial Development Corporation
- Satyajeet Dubey, Actor, (Always Kabhi Kabhi).
- Mahadev Govind Ranade – Indian lawyer, reformer and author, first batch graduate
- Man Mohan Sharma – Fellow Royal Society, Padma Vibhushan, Padma Bhushan, Former Director of MUICT (formerly known as UDCT)
- Jagdish Bhagwati – University Professor of Economics at Columbia University
- Nissim Ezekiel – Indian poet (English language)
- Anil Kakodkar – Director of BARC and Chairman of the Atomic Energy Commission and Secretary to the Government of India, Department of Atomic Energy
- Klaus Klostermaier, F.R.S.C., Professor Emeritus at the University of Manitoba, Scholar of Indian Studies
- R.A. Mashelkar – Fellow Royal Society, General, Council of Scientific and Industrial Research, India (He is an alumnus of MUICT (formerly known as UDCT))
- Mukesh Ambani – Managing Director, Reliance Industries (He is an alumnus of MUICT (formerly known as UDCT))
- Yogesh Chabria – Investor, entrepreneur and bestselling author of the Happionaire series.
- Anji Reddy – Founder, Dr. Reddy's Laboratories, Padma Shri (He is an alumnus of MUICT (formerly known as UDCT))
- Keki Hormusji Gharda – Founder, Gharda Chemicals (He is an alumnus of MUICT (formerly known as UDCT))
- Homai Vyarawalla (1913– ) – First woman photojounalist of India, Padma Vibushan
- Anant Pai – Publisher of Indian books for children especially the series Amar Chitra Katha
- Dwarkanath Kotnis – A well-known doctor in China who helped Chinese communists army during the World War II.
- Ebrahim Alkazi – Theatre director, Padma Vibhushan
- Madhuri Dixit- Popular Indian Actress
- Urmila Matondkar- Well-known Indian Actress
- Lara Dutta – Miss Universe in 2000
- Anand Patwardhan – Indian documentary film-maker
- Sunil Gavaskar – Indian cricketer (Attended St. Xavier's College)
- Smita Patil – Indian actress (Attended St. Xavier's College)
- Shabana Azmi – Indian Actress (Attended St. Xavier's College)
- Edward Hamilton Aitken – humorist, naturalist
- Ramakrishna Gopal Bhandarkar – Oriental scholar and social reformer, first batch graduate, later vice-chancellor
- Acacio Gabriel Viegas – Medical practitioner credited with the discovery of the outbreak of bubonic plague in Mumbai, India in 1896.
- Georg Bühler – Scholar of ancient Indian languages and law – fellow of University of Mumbai.
- John Samuel Malecela – Prime Minister of Tanzania from 1990–1994.
- Indira Viswanathan Peterson – Professor of Asian Studies and editor of the Norton Anthology of World Masterpieces.
- S. K. Venkataranga – lawyer and associate of Gandhi
- G.S. Maddala – American economist and mathematician
- Harish Kapadia – Himalayan Mountaineer and recipient of Patron's Medal of the Royal Geographic Society
- Mehli Mehta – Indian conductor of European classical music and father of conductor Zubin Mehta.
- Manil Suri – Indian mathematician and writer.
- Kashinath Trimbak Telang – Indian judge and oriental scholar.
- B.N. Srikrishna – Indian jurist and a Judge of the Supreme Court of India.
- Sir Pherozeshah Mehta – Indian political leader and social activist.
- Madhav Das Nalapat – Holder of the UNESCO Peace Chair.
- P. N. Bhagwati – Chief Justice of India (1985–1986)
- Bhulabhai Desai – Indian freedom fighter and lawyer.
- Vasundhara Raje – Chief Minister of the state of Rajasthan, India.
- Ranjan Ghosh – Indian screenwriter and director Aparna Sen's first co-author.
- Vidya Balan – Indian actress based in Mumbai, India.
- Gangadhar Gadgil – Marathi fiction writer.
- Rafiq Zakaria – late Indian politician and Islamic scholar.
- Pandurang Vaman Kane – Indologist and Sanskrit scholar and former Vice Chancellor of university of Mumbai.
- Mancherjee Bhownagree – British politician of Indian Parsi heritage.
- Nanabhoy Palkhivala – Indian jurist and economist.
- Sucheta Dalal – Business journalist from Mumbai, India.
- Thrity Umrigar – Journalist and author from Mumbai, India.
- Aditi Govitrikar- Mrs World 2000
- Chanda Kochhar- MD and CEO, ICICI
- Harish Manwani- Chairperson, Hindustan Uni Lever Ltd.
- Nitin Paranjape- MD & CEO, Hindustan Uni Lever Ltd.
- Zakir Naik – Muslim preacher on comparative religion
- Sanjeev Naik – MP from Thane
- Praful Patel – MP from Bhandara-Gondiya
- Sanjay Dina Patil – MP from Mumbai North East
- Nilesh Rane – MP from Ratnagiri-Sindhudurg
- Ajit Gulabchand – Industrialist, Chairman and Managing Director Hindustan Construction Company
- Ravi Gomatam – Quantum Physicist, Director of Bhaktivedanta Institute and Institute for Semantic Information Sciences and Technology, Berkeley, and Mumbai
- Virchand Gandhi - represented Jainism at the first World Parliament of Religions, Chicago in 1893 along with Vivekanand.
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