Goldberg Reaction
An example of a Goldberg reaction is the synthesis of fenamic acid, an intermediate of acridone via the Goldberg reaction:
An Ullmann-type aromatic amination reaction between an aryl iodide and an aryl amine as coupling partners has been published. The catalyst used is formed from copper(I) iodide and phenanthroline. As this reaction proceeds well with an electron-rich aryl iodide it is a valuable alternative to the Buchwald-Hartwig amination reaction, which gives best yields with electron-poor aryl halides.
The scope is extended to amides for example in the synthesis of this Camps cyclization precursor :
Read more about this topic: Ullmann Condensation
Famous quotes containing the words goldberg and/or reaction:
“The English are probably the most tolerant, least religious people on earth.”
—David Goldberg (b. 1939)
“Sole and self-commanded works,
Fears not undermining days,
Grows by decays,
And, by the famous might that lurks
In reaction and recoil,
Makes flames to freeze, and ice to boil.”
—Ralph Waldo Emerson (1803–1882)