Cast
- List of main roles
| Actor or actress | Character | Starring seasons | Recurring seasons | Episodes | Episode count |
|---|---|---|---|---|---|
| America Ferrera | Betty Suarez | all | — | 1.01–4.20 | 85 |
| Eric Mabius | Daniel Meade | all | — | 1.01–4.20 | 85 |
| Vanessa L. Williams | Wilhelmina Slater | all | — | 1.01–4.20 | 85 |
| Michael Urie | Marc St. James | all | — | 1.01–4.20 | 85 |
| Becki Newton | Amanda Tanen | all | — | 1.01–4.20 | 85 |
| Ana Ortiz | Hilda Suarez | all | — | 1.01–4.20 | 85 |
| Tony Plana | Ignacio Suarez | all | — | 1.01–4.20 | 85 |
| Mark Indelicato | Justin Suarez | all | — | 1.01–4.20 | 85 |
| Alan Dale | Bradford Meade | 1—2 | — | 1.01–2.09 | 33 |
| Ashley Jensen | Christina McKinney | 1—3 | — | 1.01–3.21, 4.18 | 66 |
| Rebecca Romijn | Alexis Meade | 1—2 | 3 | 1.13–3.04 | 33 |
| Judith Light | Claire Meade | 2—4 | 1 | 1.05–4.20 | 72 |
| Christopher Gorham | Henry Grubstick | 1—2 | 1 | 1.05–2.18, 3.01, 3.23, 4.18–4.19 | 35 |
- List of notable recurring roles
| Actor or actress | Character | Recurring seasons | Episodes | Episode count |
|---|---|---|---|---|
| Kevin Sussman | Walter | 1 | 1.01–1.16 | 16 |
| Salma Hayek | Sofia Reyes | 1 | 1.06–1.12 | 6 |
| Lindsay Lohan | Kimmie Keegan | 2—3 | 2.18–3.06 | 4 |
| Freddy Rodríguez | Gio Rossi | 2—3 | 2.03–3.04, 4.18 | 12 |
| Alec Mapa | Suzuki St. Pierre | 2—4 | 2.01–4.20 | 30 |
| Daniel Eric Gold | Matt Hartley | 3—4 | 3.15–4.11 | 20 |
| Grant Bowler | Connor Owens | 3—4 | 3.06–4.20 | 17 |
| Sarah Lafleur | Molly Meade | 3 | 3.08–3.24, 4.07 | 16 |
| Adam Rodriguez | Bobby Talercio | 4 | 4.06, 4.08–4.12, 4.14–4.15, 4.18–4.20 | 11 |
Read more about this topic: Ugly Betty
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—Propertius Sextus (c. 5016 B.C.)
“I will not cast away my physic but on those that are sick.”
—William Shakespeare (15641616)
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—Sir Walter Raleigh (15521618)