Cast
- Rob Schneider as Clive Maxtone/Jessica Spencer. Clive is a small-time criminal, and Jessica is a popular high-school girl.
- Rachel McAdams as Jessica Spencer/Clive Maxtone
- Anna Faris as April, Jessica's best friend
- Matthew Lawrence as Billy, Jessica's boyfriend
- Eric Christian Olsen as Jake, April's boyfriend
- Robert Davi as Stan, April's father
- Melora Hardin as Carol Spencer, Jessica's mother
- Angie Stone as Madame Mambuza, a purveyor of African goods
- Matt Weinberg as Booger Spencer, Jessica's cross-dressing younger brother
- Alexandra Holden as Lulu, Jessica's red-headed friend
- Maritza Murray as Keecia "Ling-Ling" Jackson, Jessica's friend, a girl of mixed racial background. She feels embarrassed by her mother's clumsy attempts to bond with her, but she learns to accept her mother and her own identity by the end of the film.
- Tia Mowry as Venetia, a high-school girl, Sissie's twin sister
- Tamera Mowry as Sissie, a high-school girl, Venetia's twin sister
- Leila Kenzle as Julie, April's mother
- Michelle Branch as As Club DJ
- Jodi Long as Keecia's enthusiastic but socially inept Korean mother
- Lee Garlington as Ms. Marjorie Bernard, the vice principal of Jessica's school
- Fay Hauser as Mrs. Thomas
- Michael O'Keefe as Richard Spencer, Jessica's father
- Sam Doumit as Eden, a Wiccan girl
- Megan Kuhlmann as Hildenburg, a heavyset girl with an interest in chemistry
- Scott Dolezal as Night Club bartender
- Maria-Elena Laas as Bianca, Jessica's social rival from another school
- Adam Sandler as Mambumza Bongo Guy (uncredited)
- Osman Soykut as The King
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