Lack of Control By Tolerogenic Dendritic Cells and T-regulatory Cells
While SI may be induced by multiple external factors, research suggests that a lack of control by tolerogenic dendritic cells and T-regulatory cells (Treg) is possibly the primary risk factor for the development of SI. In functioning immune responses, T-helper and T-cytotoxic cells are activated by presentation of antigens by antigen-presenting cells (APCs). Chief among these are dendritic cells (DCs). When a DC presents an antigen to a Treg cell, a signal is then sent to the nucleus of the DC, resulting in the production of Indoleamine 2,3- Dioxygenase (IDO). IDO inhibits T cell responses by depleting tryptophan and producing kynurenine, which is toxic to the cell.
Individuals susceptible to developing chronic systemic inflammation appear to lack proper functioning of Treg cells and TDCs. In these individuals, a lack of control of inflammatory processes results in multiple chemical and food intolerances, autoimmune diseases and many other symptoms and diseases.
Read more about this topic: Systemic Inflammation
Famous quotes containing the words lack of, lack, control and/or cells:
“The satirical rogue says here that old men have grey beards,
that their faces are wrinkled, their eyes purging thick amber
and plum-tree gum, and that they have a plentiful lack of wit,
together with most weak hams.”
—William Shakespeare (1564–1616)
“It is sometimes called the City of Magnificent Distances, but it might with greater propriety be termed the City of Magnificent Intentions.... Spacious avenues, that begin in nothing, and lead nowhere; streets, mile-long, that only want houses, roads, and inhabitants; public buildings that need but a public to be complete; and ornaments of great thoroughfares, which only lack great thoroughfares to ornament—are its leading features.”
—Charles Dickens (1812–1870)
“Our culture still holds mothers almost exclusively responsible when things go wrong with the kids. Sensing this ultimate accountability, women are understandably reluctant to give up control or veto power. If the finger of blame was eventually going to point in your direction, wouldn’t you be?”
—Ron Taffel (20th century)
“They are sworn enemies of lyric poetry.
In prison they accompany the jailer,
Enter cells to hear confessions.
Their short-end comes down
When you least expect it.”
—Charles Simic (b. 1938)