Lack of Control By Tolerogenic Dendritic Cells and T-regulatory Cells
While SI may be induced by multiple external factors, research suggests that a lack of control by tolerogenic dendritic cells and T-regulatory cells (Treg) is possibly the primary risk factor for the development of SI. In functioning immune responses, T-helper and T-cytotoxic cells are activated by presentation of antigens by antigen-presenting cells (APCs). Chief among these are dendritic cells (DCs). When a DC presents an antigen to a Treg cell, a signal is then sent to the nucleus of the DC, resulting in the production of Indoleamine 2,3- Dioxygenase (IDO). IDO inhibits T cell responses by depleting tryptophan and producing kynurenine, which is toxic to the cell.
Individuals susceptible to developing chronic systemic inflammation appear to lack proper functioning of Treg cells and TDCs. In these individuals, a lack of control of inflammatory processes results in multiple chemical and food intolerances, autoimmune diseases and many other symptoms and diseases.
Read more about this topic: Systemic Inflammation
Famous quotes containing the words lack of, lack, control and/or cells:
“Today I begin to understand what love must be, if it exists.... When we are parted, we each feel the lack of the other half of ourselves. We are incomplete like a book in two volumes of which the first has been lost. That is what I imagine love to be: incompleteness in absence.
Lying is like alcoholism. You are always recovering.”
—Steven Soderbergh (b. 1963)
“The fact that we are all trained to be mothers from infancy on means that we are all trained to devote our lives to men, whether they are our sons or not; that we are all trained to force other women to exemplify the lack of qualities which characterizes the cultural construct of femininity.”
—Andrea Dworkin (b. 1946)
“Religion differs from magic in that it is not concerned with control or manipulation of the powers confronted. Rather it means submission to, trust in, and adoration of, what is apprehended as the divine nature of ultimate reality.”
—Joachim Wach (1898–1955)
“If I’d written all the truth I knew for the past ten years, about 600 people—including me—would be rotting in prison cells from Rio to Seattle today. Absolute truth is a very rare and dangerous commodity in the context of professional journalism.”
—Hunter S. Thompson (b. 1939)