3.cxd5
White often replies 3.cxd5, but other moves are playable and may lead to transpositions into more well-known variations such as the Queen's Gambit Accepted and the Tarrasch Defense. After 3.cxd5 it is not advisable for Black to play 3...Qxd5, because either 4.Nf3 cxd4 5.Nc3 Qa5 6.Nxd4 or 5...Qd8 6.Qxd4 Qxd4 7.Nxd4 give White a big lead in development. Instead, Black should play 3...Nf6 intending to recapture on d5 with his knight. White should be able to maintain the advantage with either 4.Nf3 or 4.e4. Possible continuations are 4.Nf3 cxd4 5.Nxd4 Nxd5 6.e4 Nc7 or 4.e4 Nxe4 5.dxc5 Nxc5 6.Nc3 e6.
Read more about this topic: Symmetrical Defense