Toxicity
Unlike the edible pea, there is evidence that seeds of members of the genus Lathyrus are toxic if ingested in quantity. A related species, Lathyrus sativus, is grown for human consumption but when it forms a major part of the diet it causes symptoms of toxicity called lathyrism.
In studies of rats, animals fed a diet of 50% sweet pea seeds developed enlarged adrenals relative to control animals fed on edible peas. The main effect is thought to be on the formation of collagen. Symptoms are similar to those of scurvy and copper deficiency, which share the common feature of inhibiting proper formation of collagen fibrils. Seeds of the sweet pea contain beta-aminopropionitrile that prevents the cross-linking of collagen by inhibiting lysyl oxidase, leading to loose skin. Recent experiments have attempted to develop this chemical as a treatment to avoid disfiguring skin contractions after skin grafting.
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