Stratum Granulosum

The stratum granulosum (or granular layer) is a thin layer of cells in the epidermis. Keratinocytes migrating from the underlying stratum spinosum become known as granular cells in this layer. These cells contain keratohyalin granules, which are filled with proteins that promote hydration and crosslinking of keratin.

At the transition between this layer and the stratum corneum, cells secrete lamellar bodies (containing lipids and proteins) into the extracellular space. This results in the formation of the hydrophobic lipid envelope responsible for the skin's barrier properties. Concomitantly, cells lose their nuclei and organelles causing the granular cells to become non-viable corneocytes in the stratum corneum.

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Famous quotes containing the word stratum:

    If you chance to live and move and have your being in that thin stratum in which the events that make the news transpire,—thinner than the paper on which it is printed,—then these things will fill the world for you; but if you soar above or dive below that plane, you cannot remember nor be reminded of them.
    Henry David Thoreau (1817–1862)