The stratum granulosum (or granular layer) is a thin layer of cells in the epidermis. Keratinocytes migrating from the underlying stratum spinosum become known as granular cells in this layer. These cells contain keratohyalin granules, which are filled with proteins that promote hydration and crosslinking of keratin.
At the transition between this layer and the stratum corneum, cells secrete lamellar bodies (containing lipids and proteins) into the extracellular space. This results in the formation of the hydrophobic lipid envelope responsible for the skin's barrier properties. Concomitantly, cells lose their nuclei and organelles causing the granular cells to become non-viable corneocytes in the stratum corneum.
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Famous quotes containing the word stratum:
“Once it chanced that I stood in the very abutment of a rainbow’s arch, which filled the lower stratum of the atmosphere, tinging the grass and leaves around, and dazzling me as if I looked through colored crystal. It was a lake of rainbow light, in which, for a short while, I lived like a dolphin. If it had lasted longer it might have tinged my employments and my life.”
—Henry David Thoreau (1817–1862)