Spen

SPEN

Identifiers Symbols SPEN; HIAA0929; MINT; RBM15C; SHARP External IDs OMIM: 613484 MGI: 1891706 HomoloGene: 124461 GeneCards: SPEN Gene

Gene Ontology
Molecular function	• nucleotide binding • RNA polymerase II transcription factor binding • RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription • single-stranded DNA binding • sequence-specific DNA binding transcription factor activity • transcription corepressor activity • RNA binding • protein binding
Cellular component	• nucleus • nucleolus • transcriptional repressor complex
Biological process	• negative regulation of transcription from RNA polymerase II promoter • Notch signaling pathway • virus-host interaction • negative regulation of transcription, DNA-dependent • positive regulation of transcription, DNA-dependent • positive regulation of neurogenesis
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 23013 56381 Ensembl ENSG00000065526 ENSMUSG00000040761 UniProt Q96T58 Q62504 RefSeq (mRNA) NM_015001 NM_019763 RefSeq (protein) NP_055816 NP_062737 Location (UCSC) Chr 1:
16.17 – 16.27 Mb Chr 4:
141.47 – 141.54 Mb PubMed search

Msx2-interacting protein is a protein that in humans is encoded by the SPEN gene.