Soyuz 11

Soyuz 11 (Russian: Союз 11, Union 11) was the first and only manned mission to board the world's first space station, Salyut 1 (Soyuz 10 had soft-docked but had not been able to enter due to latching issues). The mission arrived at the space station on June 7, 1971 and departed on June 30, 1971. The mission ended in disaster when the crew capsule depressurized during preparations for re-entry, killing the three-man crew. This accident resulted in the only confirmed human deaths to occur in space (as opposed to high atmosphere). The crew members aboard Soyuz 11 were Vladislav Volkov, Georgi Dobrovolski and Viktor Patsayev.

Read more about Soyuz 11:  Crew, Mission Parameters, Mission Highlights, Death of Crew