Sonic Hedgehog
| Gene Ontology | |
|---|---|
| Molecular function | • glycoprotein binding • signal transducer activity • patched binding • calcium ion binding • protein binding • glycosaminoglycan binding • peptidase activity • zinc ion binding • morphogen activity • laminin-1 binding |
| Cellular component | • extracellular space • nucleus • endoplasmic reticulum • Golgi apparatus • plasma membrane • cell surface • transport vesicle • extracellular matrix • membrane raft |
| Biological process | • negative regulation of transcription from RNA polymerase II promoter • patterning of blood vessels • vasculogenesis • metanephros development • branching involved in ureteric bud morphogenesis • response to hypoxia • cell fate specification • neural crest cell migration • neural tube formation • heart looping • positive regulation of neuroblast proliferation • osteoblast development • lymphoid progenitor cell differentiation • determination of left/right asymmetry in lateral mesoderm • proteolysis • endocytosis • apoptotic process • smoothened signaling pathway • positive regulation of hh target transcription factor activity • cell-cell signaling • pattern specification process • ectoderm development • neuroblast proliferation • axon guidance • central nervous system development • ventral midline development • hindgut morphogenesis • digestive tract mesoderm development • heart development • blood coagulation • androgen metabolic process • positive regulation of cell proliferation • embryo development • embryonic pattern specification • anterior/posterior pattern specification • dorsal/ventral pattern formation • response to organic nitrogen • oligodendrocyte development • positive regulation of skeletal muscle cell proliferation • myotube differentiation • intein-mediated protein splicing • ventral spinal cord interneuron specification • dorsal/ventral neural tube patterning • smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation • telencephalon regionalization • establishment of cell polarity • regulation of proteolysis • positive regulation of Wnt receptor signaling pathway • lung development • embryonic limb morphogenesis • negative regulation of cell migration • male genitalia development • prostate gland development • regulation of epithelial cell differentiation • thyroid gland development • forebrain development • midbrain development • hindbrain development • pancreas development • hair follicle morphogenesis • response to estradiol stimulus • negative regulation of proteasomal ubiquitin-dependent protein catabolic process • response to retinoic acid • regulation of protein localization • T cell differentiation in thymus • positive regulation of T cell differentiation in thymus • positive regulation of immature T cell proliferation in thymus • negative regulation of transcription elongation from RNA polymerase II promoter • protein localization to nucleus • embryonic forelimb morphogenesis • embryonic hindlimb morphogenesis • regulation of cell proliferation • negative regulation of T cell proliferation • positive regulation of protein import into nucleus • odontogenesis of dentin-containing tooth • embryonic digit morphogenesis • camera-type eye development • negative regulation of apoptotic process • CD4-positive or CD8-positive, alpha-beta T cell lineage commitment • tongue morphogenesis • skin development • positive thymic T cell selection • negative thymic T cell selection • intermediate filament organization • myoblast differentiation • response to ethanol • negative regulation of cell differentiation • positive regulation of smoothened signaling pathway • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • positive regulation of photoreceptor cell differentiation • positive regulation of alpha-beta T cell differentiation • negative regulation of alpha-beta T cell differentiation • cell development • thymus development • embryonic digestive tract morphogenesis • embryonic foregut morphogenesis • positive regulation of skeletal muscle tissue development • organ formation • neuron fate commitment • response to axon injury • embryonic skeletal system development • positive regulation of oligodendrocyte differentiation • branching morphogenesis of a tube • male genitalia morphogenesis • inner ear development • formation of anatomical boundary • stem cell development • positive regulation of striated muscle cell differentiation • positive regulation of cell division • Bergmann glial cell differentiation • palate development • canonical Wnt receptor signaling pathway • limb bud formation • positive regulation of penile erection • lung epithelium development • trachea morphogenesis • branching involved in salivary gland morphogenesis • bud outgrowth involved in lung branching • right lung development • left lung development • lung lobe morphogenesis • lung-associated mesenchyme development • primary prostatic bud elongation • prostate epithelial cord elongation • salivary gland cavitation • epithelial cell proliferation involved in salivary gland morphogenesis • regulation of prostatic bud formation • epithelial-mesenchymal signaling involved in prostate gland development • positive regulation of epithelial cell proliferation involved in prostate gland development • regulation of mesenchymal cell proliferation involved in prostate gland development • mesenchymal smoothened signaling pathway involved in prostate gland development • artery development • mesenchymal cell proliferation involved in lung development • somite development • positive regulation of sclerotome development • positive regulation of oligodendrocyte progenitor proliferation • cellular response to lithium ion • renal system development • metanephric mesenchymal cell proliferation involved in metanephros development • multicellular structure septum development • negative regulation of canonical Wnt receptor signaling pathway • negative regulation of cholesterol efflux • regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry • negative regulation of ureter smooth muscle cell differentiation • positive regulation of ureter smooth muscle cell differentiation • negative regulation of kidney smooth muscle cell differentiation • positive regulation of kidney smooth muscle cell differentiation • positive regulation of mesenchymal cell proliferation involved in ureter development |
| Sources: Amigo / QuickGO | |
155.59 – 155.6 Mb
28.46 – 28.47 Mb
Sonic hedgehog homolog (SHH) is one of three proteins in the mammalian signaling pathway family called hedgehog, the others being desert hedgehog (DHH) and Indian hedgehog (IHH). SHH is the best studied ligand of the hedgehog signaling pathway. It plays a key role in regulating vertebrate organogenesis, such as in the growth of digits on limbs and organization of the brain. Sonic hedgehog is the best established example of a morphogen as defined by Lewis Wolpert's French flag model—a molecule that diffuses to form a concentration gradient and has different effects on the cells of the developing embryo depending on its concentration. SHH remains important in the adult. It controls cell division of adult stem cells and has been implicated in development of some cancers.
Read more about Sonic Hedgehog: Discovery, Function, Processing, Robotnikinin, Criticism of The Name