Small Molecule - Primary and Secondary Metabolites

Primary and Secondary Metabolites

For organisms to produce small molecules they need one or more specialized enzymes (to create and destroy), which as a result are not that varied in vertebrates (recent and small + slow population size), but very common in soil bacteria (such as streptomyces) and fungi, which in particular secrete antibiotics.

Plants also have several secondary metabolites, which play a role in cell signalling, pigmentation or in defence, several of which have also been used as drugs (medical and recreational):

  • Alkaloids
  • Glycosides
  • Lipids
  • Flavonoids
  • Nonribosomal peptides, such as actinomycin-D
  • Phenazines
  • Phenols
  • Polyketide
  • Terpenes, including steroids
  • Tetrapyrroles.

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