Simon Amstell - Never Mind The Buzzcocks

Amstell first appeared on the comedy pop quiz show Never Mind the Buzzcocks as a guest during Mark Lamarr's tenure as host, in 2003 and 2006. Following Lamarr's departure, he was one of the series' guest hosts before being appointed as permanent host beginning in October 2006. He said at the time that he hoped to beat "the universal, exceptionless rule that when a new host takes over an old show it is a horrible, embarrassing disaster".

In June 2007, Amstell and long-term collaborator Dan Swimer wrote Imagine... A Mildly Amusing Panel Show, a spoof version of Alan Yentob's arts programme Imagine. Yentob and Amstell play themselves in a mock interview between what a number of commentators described as "overtly sexual" clips taken from Amstell's Never Mind the Buzzcocks episodes. It was followed in February 2008 by Never Mind the Buzzcocks: A Moving Tribute, which jokingly implied that Amstell had either died or retired from the show.

On 25 April 2009, Amstell announced via his internet mailing list that he would not be hosting another series of Never Mind the Buzzcocks because of his desire to instead concentrate on his live tours and stand-up performances.

Amstell won several awards for his work on Never Mind the Buzzcocks. In March 2007, he won the 2006 Royal Television Society Award for Best Entertainment Performance. In December 2007, he won two British Comedy Awards for Best Comedy Entertainment Personality and Best Comedy Entertainment Series for Never Mind the Buzzcocks. In addition, Never Mind the Buzzcocks won the Best Entertainment Programme award at the Broadcast Awards 2008. Amstell's era was the reason why Never Mind the Buzzcocks was chosen as the 36th-best TV show of the decade by The Times.