Sierra Madre (Spanish for "mother mountain range") may refer to one of several mountain ranges:
- In Mexico:
- Sierra Madre Occidental, a mountain range in northwestern Mexico and southern Arizona
- Sierra Madre Oriental, a mountain range in northeastern Mexico
- Sierra Madre de Oaxaca, a mountain range in south-central Mexico
- Sierra Madre del Sur, a mountain range in southern Mexico
- Sierra Madre de Chiapas, a mountain range which extends from southeastern Mexico
- In Central America:
- Sierra Madre de Chiapas, the continuation of this mountain range crossing southern Guatemala, northern El Salvador, and western Honduras
- In the Philippines:
- Sierra Madre (Philippines), a mountain range on Luzon island
- In the United States:
- Sierra Madre Mountains (California), a mountain range in the state of California
- Sierra Madre, California, a town in Los Angeles County located at the foot of the San Gabriel Mountains
- Sierra Madre Range (Wyoming), a mountain range in the south central portion of the state
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