Sideroblastic Anemia - Classification

Classification

Sideroblastic anemia is typically divided into subtypes based on its cause.

  • Hereditary or congenital sideroblastic anemia may be X-linked or autosomal.
OMIM Name Gene
300751 X-linked sideroblastic anemia (XLSA) ALAS2
301310 sideroblastic anemia with spinocerebellar ataxia (ASAT) ABCB7
205950 pyridoxine-refractory autosomal recessive sideroblastic anemia SLC25A38
206000 pyridoxine-responsive sideroblastic anemia (vitamin B6 deficiency; pyridoxal phosphate required for heme synthesis)

GLRX5 has also been implicated.

  • Acquired, or secondary, sideroblastic anemia develops after birth and is divided according to its cause.

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