Sher Khan, Shir Khan, or Shere Khan, may refer to:
- Sher Shah Suri (1486–1545), founder of the Sur Empire and ruler of northern India in the 16th century
- Sher Afghan Quli Khan (died 1607), Mughal courtier of the 17th century
- Sher Ali Khan (1825–1879), Amir of Afghanistan between 1863 and 1879
- Sher Khan Nashir, Afghan politician from Kunduz Province in the 1930s
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