- 1998
- WTA Newcomer of the Year
- Tennis Magazine/Rolex Rookie of the Year
- 1999
- WTA Most Improved Player of the Year
- Tennis Magazine Player of the Year
- 2000
- WTA Doubles Team of the Year Award (with Venus Williams)
- Teen Choice Awards – Extraordinary Achievement Award
- Forbes The Celebrity 100 (No.68)
- Women's Sports Foundation Sportswoman of the Year for team sports (with Venus Williams)
- 2001
- Forbes The Celebrity 100 (No.71)
- 2002
- Associated Press Female Athlete of the Year
- WTA Player of the Year
- ITF Women's Singles World Champion
- Forbes The Celebrity 100 (No.72)
- 2003
- 34th NAACP Image Awards President's Award
- Best Female Athlete ESPY Award
- Best Female Tennis Player ESPY Award
- Laureus World Sportswoman of the Year
- Avon Foundation Celebrity Role Model Award
- BET Award for Female Athlete of the Year
- Forbes The Celebrity 100 (No.60)
- 2004
- WTA Comeback Player of the Year
- Family Circle/Prudential Financial Player Who Makes a Difference Award
- Best Female Tennis Player ESPY Award
- BET Award for Female Athlete of the Year
- Forbes The Celebrity 100 (No.63)
- Harris Poll Top 10 Favorite Female Sports Star (No.2)
- 2005
- BET Award for Female Athlete of the Year
- Forbes The Celebrity 100 (No.62)
- Harris Poll Top 10 Favorite Female Sports Star (No.2)
- 2006
- Forbes The Celebrity 100 (No.87)
- Harris Poll Top 10 Favorite Female Sports Star (No.2)
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- 2007
- BET Award for Female Athlete of the Year
- Laureus World Comeback of the Year
- Harris Poll Top 10 Favorite Female Sports Star (No.1)
- Forbes The Celebrity 100 (No.69)
- 2008
- WTA Player of the Year
- Forbes The Celebrity 100 (No.69)
- Harris Poll Top 10 Favorite Female Sports Star (No.2)
- 2009
- AP Female Athlete of The Year Award
- SI.com Best Female Athlete of the Decade
- Glamour Magazine Women of the Year Award
- BET Award for Female Athlete of the Year
- Harris Poll Top 10 Favorite Female Sports Star (No.1)
- Best Female Tennis Player ESPY Award
- ITF Women's Singles World Champion
- ITF Women's Doubles World Champion (with Venus Williams)
- Named Second Best Tennis Player of the Decade by ESPN (with Roger Federer at Number 1)
- WTA Player of the Year
- WTA Doubles Team of the Year Award (with Venus Williams)
- WTA Fan Favorite Doubles Team of the Year Award (with Venus Williams)
- Doha 21st Century Leaders Awards – Outstanding Leadership
- Forbes The Celebrity 100 (No.67)
- 2010
- Laureus World Sportswoman of the Year
- TIME Magazine The World's 100 Most Influential People
- Forbes The Celebrity 100 (No.61)
- BET Award for Female Athlete of the Year
- Best Female Tennis Player ESPY Award
- Harris Poll Top 10 Favorite Female Sports Star (No.1)
- WTA Fan Favorite Doubles Team of the Year Award (with Venus Williams)
- Forbes 30 Utterly Inspiring Role Models
- Teen Choice Awards – Female Athlete Award
- Forbes 100 Most Powerful Women in the World (No.55)
- 2011
- BET Award for Female Athlete of the Year
- Forbes The Celebrity 100 (No.84)
- TIME Magazine 30 Legends of Women's Tennis
- Best Female Tennis Player ESPY Award
- Forbes Most Powerful Black Women in the U.S. (No.10)
- The Root 100 2011: Influencers and Iconoclasts (No.41)
- Harris Poll Top 10 Favorite Female Sports Star (No.1)
- 2012
- Forbes The Celebrity 100 (No.77)
- BET Award for Sportswoman of the Year
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