Sephardi Jews - Genetics

Genetics

Due to their origin in the Mediterranean basin, there is a higher incidence of certain hereditary diseases and inherited disorders in Sephardi Jews. However, there are no specifically Sephardic genetic diseases, since the diseases in this group are not common to Sephardic Jews in general, but are instead common in the particular country of birth. The most important ones are:

• Beta-Thalassemia
• Familial Mediterranean fever
• Glucose-6-phosphate dehydrogenase deficiency and Gilbert's Syndrome
• Glycogen storage disease type III
• Machado-Joseph disease
• Hereditary Inclusion Body Myopathy

A study by the International Institute of Anthropology in Paris, France, confirmed similarities in the Y-haplotype frequencies in Lebanese, Palestinian, and Sephardic Jewish men, identifying them as "three Near-Eastern populations sharing a common geographic origin."