Second Gas Effect
During induction of general anesthesia when a large volume of nitrous oxide is taken up from alveoli into pulmonary capillary blood, the concentration of gases remaining in the alveoli is increased. This results in effects known as the "concentration effect" and the "second gas effect". These effects occur because of the contraction in volume associated with the uptake of the nitrous oxide. Previous explanations by Eger and Stoelting have appealed to an extra-inspired tidal volume due to a potential negative intrapulmonary pressure associated with the uptake of the nitrous oxide.
In the first reference below, it is shown that there are two extreme breathing patterns and that the extra-inspired tidal volume is an artificial construct associated with one of these patterns. Thus it is the volume change that actually causes the effects.
Read more about Second Gas Effect: Stedman's Medical Dictionary
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