Types
Scavenger receptors are categorized into classes A, B, and C according to their structural characteristics.
- Class A is mainly expressed in the macrophage, and a protein whose molecular weight is about 80 kDa makes a trimer; it is composed of 1) cytosol domain, 2) transmembrane domain, 3) spacer domain, 4) alpha-helical coiled-coil domain, 5) collagen-like domain, and 6) cysteine-rich domain.
- Class B has two transmembrane regions.
- Class C is a transmembrane protein whose N-terminus is located extracellularly.
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