Robert Gallo - Retrovirus Work

Retrovirus Work

After listening to a talk by biologist David Baltimore, Gallo became interested in the study of retroviruses, and made their study the primary activity of his lab. In 1976, Doris Morgan, a researcher in Gallo's lab, was successful in growing T lymphocytes. Frank Ruscetti, Gallo, and Morgan coauthored a paper in Science describing their method. Morgan and Ruscetti eventually identified this as being dependent upon the activity of Blastogenic Factor, the T-cell growth factor previously discovered by Julius Gordon in 1965, later renamed as IL-2 (interleukin-2) by Kendall A. Smith. These breakthroughs allowed researchers to grow T-cells and study the viruses that affect them, such as human T-cell leukemia virus, or HTLV, the first retrovirus identified in humans, which Bernard Poiesz and Ruscetti isolated in Gallo's lab. HTLV's role in leukemia was clarified when a group of Japanese researchers, puzzling over an outbreak of a rare form of the disease, independently isolated the same retrovirus and showed it was the cause. In 1982, Gallo received the prestigious Lasker Award: “For his pioneering studies that led to the discovery of the first human RNA tumor virus and its association with certain leukemias and lymphomas.” In 2009, Robert Gallo received the Dan David Prize of the Dan David Foundation and Tel Aviv University.