Splicing Errors
Common errors:
- Mutation of a splice site resulting in loss of function of that site. Results in exposure of a premature stop codon, loss of an exon, or inclusion of an intron.
- Mutation of a splice site reducing specificity. May result in variation in the splice location, causing insertion or deletion of amino acids, or most likely, a disruption of the reading frame.
- Displacement of a splice site, leading to inclusion or exclusion of more RNA than expected, resulting in longer or shorter exons.
Many splicing errors are safeguarded by a cellular quality control mechanism termed nonsense-mediated mRNA decay (NMD).
Read more about this topic: RNA Splicing
Famous quotes containing the word errors:
“When people put their ballots in the boxes, they are, by that act, inoculated against the feeling that the government is not theirs. They then accept, in some measure, that its errors are their errors, its aberrations their aberrations, that any revolt will be against them. It’s a remarkably shrewed and rather conservative arrangement when one thinks of it.”
—John Kenneth Galbraith (b. 1908)