Splicing Errors
Common errors:
- Mutation of a splice site resulting in loss of function of that site. Results in exposure of a premature stop codon, loss of an exon, or inclusion of an intron.
- Mutation of a splice site reducing specificity. May result in variation in the splice location, causing insertion or deletion of amino acids, or most likely, a disruption of the reading frame.
- Displacement of a splice site, leading to inclusion or exclusion of more RNA than expected, resulting in longer or shorter exons.
Many splicing errors are safeguarded by a cellular quality control mechanism termed nonsense-mediated mRNA decay (NMD).
Read more about this topic: RNA Splicing
Famous quotes containing the word errors:
“Their errors have been weighed and found to have been dust in the balance; if their sins were as scarlet, they are now white as snow: they have been washed in the blood of the mediator and the redeemer, Time.”
—Percy Bysshe Shelley (1792–1822)