Replication
When a human or animal is injected with infected saliva, the rabies virus replicates at the site of inoculation. Aided by the G protein, the viral envelope attaches and fuses with the host cell membrane. Invagination of the plasma membrane with clathrin-coated pits allows cytoplasmic absorption via pinocytosis. The virions aggregate with the large endosomes, and after fusion with their membranes, they initiate the uncoating and release of the viral RNP into the cytoplasm. Since the rabies virus has a linear –ssRNA genome, messenger RNAs are produced to permit virus replication using the host cell machinery. In particular, translation of the genome occurs on the free ribosomes in the cytoplasm, and some posttranslational processing occurs in the endoplasmic reticulum and Golgi apparatus.
Read more about this topic: Rabies Virus