Quinolone Antibiotics
The quinolones are a family of synthetic broad-spectrum antibacterial drugs The first generation of the quinolones began with the introduction of nalidixic acid in 1962 for treatment of urinary tract infections in humans. Nalidixic acid was discovered by George Lesher and coworkers in a distillate during an attempt at chloroquine synthesis.
They prevent bacterial DNA from unwinding and duplicating. (See Mechanism of Action)
Quinolones, in comparison to other antibiotic classes, have among the highest risk of causing colonization with MRSA and Clostridium difficile. The majority of quinolones in clinical use belong to the subset fluoroquinolones, which have a fluorine atom attached to the central ring system, typically at the 6-position or C-7 position.
Read more about Quinolone Antibiotics: Medical Uses, Adverse Effects, Contraindications, Pharmacology, Mechanism of Action, Interactions, Antibiotic Misuse and Bacterial Resistances, History, Generations, Veterinary Use
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