Quaternary Ammonium Cation - Synthesis

Synthesis

Quaternary ammonium compounds are prepared by alkylation of tertiary amines, in a process called quaternization. Typically one of the alkyl groups on the amine is larger than the others. A typical synthesis is for benzalkonium chloride from a long-chain alkyldimethylamine and benzyl chloride:

CH3(CH2)nN(CH3)2 + ClCH2C6H5 → +Cl-

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