The aim of quantitative proteomics is to obtain quantitative information about all proteins in a sample. Rather than just providing lists of proteins identified in a certain sample, quantitative proteomics yields information about differences between samples. For example, this approach can be used to compare samples from healthy and diseased patients. The methods for protein identification are identical to those used in general (i.e. qualitative) proteomics, but include quantification as an additional dimension. Quantitative proteomics mainly uses the technology of mass spectrometry (MS) to detect the changes of the protein. Moreover, MS technology can also identify and quantitate the changes.
Read more about Quantitative Proteomics: The History of Modern Quantitative Proteomics, Discovery Vs. Targeted Proteomics, Relative and Absolute Quantitative Proteomics, When To Use Relative or Absolute Quantitation Strategies, Two-dimensional Gel Electrophoresis