Pulmonary Surfactant - Artificial Surfactants

Artificial Surfactants

Synthetic pulmonary surfactants

  1. Exosurf - a mixture of DPPC with hexadecanol and tyloxapol added as spreading agents
  2. Pumactant (Artificial Lung Expanding Compound or ALEC) - a mixture of DPPC and PG
  3. KL-4 - composed of DPPC, palmitoyl-oleoyl phosphatidylglycerol, and palmitic acid, combined with a 21 amino acid synthetic peptide that mimics the structural characteristics of SP-B.
  4. Venticute - DPPC, PG, palmitic acid and recombinant SP-C

Animal derived surfactants

  1. Alveofact - extracted from cow lung lavage fluid
  2. Curosurf - extracted from material derived from minced pig lung
  3. Infasurf - extracted from calf lung lavage fluid
  4. Survanta - extracted from minced cow lung with additional DPPC, palmitic acid and tripalmitin

Exosurf, Curosurf, Infasurf, and Survanta are the surfactants currently FDA approved for use in the U.S.

Read more about this topic:  Pulmonary Surfactant

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