Secretion
Many types of medications are secreted in the proximal tubule. Further reading: Table of medication secreted in kidney
Most of the ammonium that is excreted in the urine is formed in the proximal tubule via the breakdown of glutamine to alpha-ketoglutarate. This takes place in two steps, each of which generates an ammonium anion: the conversion of glutamine to glutamate and the conversion of glutamate to alpha-ketoglutarate. The alpha-ketoglutarate generated in this process is then further broken down to form two bicarbonate anions, which are pumped out of the basolateral portion of the tubule cell by cotransport with sodium ions.
Read more about this topic: Proximal Convoluted Tubule
Related Phrases
Related Words