History
Understanding of the tertiary structure of proteins and their determinants, though important, represent a long standing issue in biochemistry. The first predicted structure of globular proteins was the cyclol model of Dorothy Wrinch, but this was quickly discounted as being inconsistent with experimental data. Modern methods are sometimes able to predict the tertiary structure de novo to within 5 Å for small proteins (<120 residues) and under favorable conditions, e.g., confident secondary structure predictions.
Read more about this topic: Protein Tertiary Structure
Famous quotes containing the word history:
“Free from public debt, at peace with all the world, and with no complicated interests to consult in our intercourse with foreign powers, the present may be hailed as the epoch in our history the most favorable for the settlement of those principles in our domestic policy which shall be best calculated to give stability to our Republic and secure the blessings of freedom to our citizens.”
—Andrew Jackson (1767–1845)
“Perhaps universal history is the history of the diverse intonation of some metaphors.”
—Jorge Luis Borges (1899–1986)
“The history of persecution is a history of endeavors to cheat nature, to make water run up hill, to twist a rope of sand.”
—Ralph Waldo Emerson (1803–1882)