History
Understanding of the tertiary structure of proteins and their determinants, though important, represent a long standing issue in biochemistry. The first predicted structure of globular proteins was the cyclol model of Dorothy Wrinch, but this was quickly discounted as being inconsistent with experimental data. Modern methods are sometimes able to predict the tertiary structure de novo to within 5 Å for small proteins (<120 residues) and under favorable conditions, e.g., confident secondary structure predictions.
Read more about this topic: Protein Tertiary Structure
Famous quotes containing the word history:
“The history of literature—take the net result of Tiraboshi, Warton, or Schlegel,—is a sum of a very few ideas, and of very few original tales,—all the rest being variation of these.”
—Ralph Waldo Emerson (1803–1882)
“As I am, so shall I associate, and so shall I act; Caesar’s history will paint out Caesar.”
—Ralph Waldo Emerson (1803–1882)
“In the history of the United States, there is no continuity at all. You can cut through it anywhere and nothing on this side of the cut has anything to do with anything on the other side.”
—Henry Brooks Adams (1838–1918)