History
Understanding of the tertiary structure of proteins and their determinants, though important, represent a long standing issue in biochemistry. The first predicted structure of globular proteins was the cyclol model of Dorothy Wrinch, but this was quickly discounted as being inconsistent with experimental data. Modern methods are sometimes able to predict the tertiary structure de novo to within 5 Å for small proteins (<120 residues) and under favorable conditions, e.g., confident secondary structure predictions.
Read more about this topic: Protein Tertiary Structure
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There are only two great currents in the history of mankind: the baseness which makes conservatives and the envy which makes revolutionaries.”
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—Henry David Thoreau (1817–1862)
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Figuring the natures of the times deceased,
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With a near aim, of the main chance of things
As yet not come to life.”
—William Shakespeare (1564–1616)