Prostate Biopsy - Negative Biopsy

Negative Biopsy

Biopsies detect prostate cancer in about 25% of men with abnormal screening tests. However a negative biopsy does not ensure the absence of disease. Repeat prostate biopsies are positive in about 25-30% of patients whose initial biopsy was negative.

During a biopsy procedure, less than 1 percent of the entire prostate gland is sampled, so men can harbor prostate cancer in spite of having a negative initial biopsy.

Recently in order to address this problem, researchers have examined the ability of mitochondrial DNA to help diagnose prostate cancer in negative biopsy samples.

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