The prolactin receptor—encoded by a gene on Chromosome 5p13-14—interacts with the prolactin molecule as a transmembrane receptor.
Thus it contains an extracellular region that binds prolactin, a transmembrane region, and a cytoplasmatic region.
The receptor is a cytokine receptor, and second messenger cascades include the JAK-STAT pathway, JAK-RUSH pathway, Ras-Raf-MAPK, and PI-3K.
There may be variation among different tissue prolactin receptors.
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