Function
Progesterone is necessary to induce the progesterone receptors. When no binding hormone is present the carboxyl terminal inhibits transcription. Binding to a hormone induces a structural change that removes the inhibitory action. Progesterone antagonists prevent the structural reconfiguration.
After progesterone binds to the receptor, restructuring with dimerization follows and the complex enters the nucleus and binds to DNA. There transcription takes place, resulting in formation of messenger RNA that is translated by ribosomes to produce specific proteins.
Read more about this topic: Progesterone Receptor
Famous quotes containing the word function:
“The uses of travel are occasional, and short; but the best fruit it finds, when it finds it, is conversation; and this is a main function of life.”
—Ralph Waldo Emerson (1803–1882)
“The function of comedy is to dispel ... unconsciousness by turning the searchlight of the keenest moral and intellectual analysis right on to it.”
—George Bernard Shaw (1856–1950)
“Uses are always much broader than functions, and usually far less contentious. The word function carries overtones of purpose and propriety, of concern with why something was developed rather than with how it has actually been found useful. The function of automobiles is to transport people and objects, but they are used for a variety of other purposes—as homes, offices, bedrooms, henhouses, jetties, breakwaters, even offensive weapons.”
—Frank Smith (b. 1928)