Phytic Acid - Biological and Physiological Roles

Biological and Physiological Roles

Although undigestable for many animals (as explained above), phytic acid and its metabolites as they occur in seeds and grains have several important roles for the seedling plant. Most notably, phytic acid functions as a phosphorus store, as an energy store, as a source of cations and as a source of myoinositol (a cell wall precursor). Phytic acid is the principal storage forms of phosphorus in plant seeds.

In animal cells, myoinositol polyphosphates are ubiquitous, and phytic acid (myoinositol hexakisphosphate) is the most abundant, with its concentration ranging from 10 to 100 uM in mammalian cells, depending on cell type and developmental stage. This compound is not obtained from the animal diet, but must be synthesized inside the cell from phosphate and inositol (which in turn is produced from glucose, usually in the kidneys). The interaction of intracellular phytic acid with specific intracellular proteins has been investigated in vitro, and these interactions have been found to result in the inhibition or potentiation of the physiological activities of those proteins. The best evidence from these studies suggests an intracellular role for phytic acid as a cofactor in DNA repair by nonhomologous end-joining. Other studies using yeast mutants have also suggested intracellular phytic acid may be involved in mRNA export from the nucleus to the cytosol. There are still major gaps in the understanding of this molecule, and the exact pathways of phytic acid and lower inositol phosphate metabolism are still unknown. As such, the exact physiological roles of intracellular phytic acid are still a matter of debate.